|
Symbol Name ID |
Tlr5
toll-like receptor 5 MGI:1858171 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Leukopenia |
Sinusitis |
Chronic sinusitis |
Pericarditis |
Lymphadenopathy |
Hepatosplenomegaly |
Pancreatitis |
Lupus nephritis |
Nephritis |
Abnormality of the immune system |
Discoid lupus rash |
Malar rash |
Recurrent pneumonia |
Serositis |
Decreased circulating complement C3 concentration |
Decreased circulating complement C4 concentration |
Antineutrophil antibody positivity |
Perinuclear antineutrophil antibody positivity |
Antinuclear antibody positivity |
Anti-dsDNA antibody positivity |
Anti-La/SS-B antibody positivity |
Anti-Sm antibody positivity |
Anti-U1 ribonucleoprotein antibody positivity |
Antiphospholipid antibody positivity |
Systemic lupus erythematosus |
Asthma |
Nontuberculous mycobacterial pulmonary infection |
Recurrent Burkholderia cepacia infections |
Recurrent Haemophilus influenzae infections |
Recurrent Staphylococcus aureus infections |
Recurrent Aspergillus infections |
Recurrent respiratory infections |
Recurrent bronchopulmonary infections |
Recurrent lower respiratory tract infections |
| Disease(s) Associated with TLR5 | ||||||||||||||||||||||||||||||||||
| cystic fibrosis | ||||||||||||||||||||||||||||||||||
| systemic lupus erythematosus |
| Mouse Phenotypes | immune system phenotype |
abnormal leukocyte migration |
increased susceptibility to colitis induced morbidity/mortality |
increased susceptibility to induced colitis |
large intestinal inflammation |
increased susceptibility to induced pancreatitis |
enlarged spleen |
decreased neutrophil cell number |
abnormal macrophage physiology |
abnormal dendritic cell physiology |
abnormal cytokine secretion |
increased interleukin-1 beta secretion |
decreased interleukin-12b secretion |
decreased interleukin-6 secretion |
increased susceptibility to autoimmune diabetes |
lung inflammation |
decreased susceptibility to bacterial infection |
increased susceptibility to bacterial infection |
abnormal response to transplant |
|
| Availability | Mouse Genotype | |||||||||||||||||||
| Tlr5tm1Aki/Tlr5tm1Aki | * | |||||||||||||||||||
| Tlr5tm1Flv/Tlr5tm1Flv | ||||||||||||||||||||
| Tlr5tm1.1Gewr/Tlr5tm1.1Gewr Tg(Itgax-cre,-EGFP)4097Ach/? (conditional) |
* | |||||||||||||||||||
| Tg(Vil1-cre)997Gum/? Tlr5tm1.1Gewr/Tlr5tm1.1Gewr (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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